CASE REPORT
Year : 2014  |  Volume : 16  |  Issue : 1  |  Page : 35-38

Management of Graves' disease during pregnancy in developing countries: A report of two cases and a review of the literature


1 Department of Medicine, Irrua Specialist Teaching Hospital, P.M.B 08, Irrua, Edo State, Nigeria
2 Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital, P.M.B 08, Irrua, Edo State, Nigeria

Correspondence Address:
Dr. Kennedy I. Akhuemokhan
Department of Internal Medicine, Irrua Specialist Teaching Hospital, P.M.B 08, Irrua, Edo State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2276-7096.132577

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Grave's disease account for about 85% of hyperthyroidism during pregnancy. If not properly managed, it can result in severe maternal, fetal and neonatal morbidity and mortality. Anti-thyroid drugs are the main treatment for Grave's disease during pregnancy. The lowest possible dose should be used to maintain maternal free thyroxine levels at or just above the upper limit of the normal non-pregnant normal range. Fetal thyroid function depends on the balance between the trans-placental passage of thyroid-stimulating maternal antibodies and thyroid-inhibiting anti-thyroid drugs. In developing countries where propylthiouracil is either expensive or not available the use of carbimazole at lower doses is safe. Two cases are here presented to buttress this view.


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